裴晓静,博士,副教授,硕士生导师
联系方式:pxj@btbu.edu.cn
通讯地址:北京市海淀区阜成路11号
教育及工作经历:
2026.4至今,yl7703永利集团官网轻工科学与工程公司化妆品系,副教授。
2020.10-2026.4,yl7703永利集团官网轻工科学与工程公司化学系,副教授。
2019.07-2020.10,yl7703永利集团官网理公司化学系,讲师。
2014.09-2019.07,北京大学,分析化学专业硕博连读,获理学博士学位。
2010.09-2014.07,山东师范大学,应用化学专业,获理学学士学位。
研究领域:
1. 核酸相关化妆品研发及转化;
2. PDRN微球化研究及转化;
3. 化妆品创新制剂研究及转化;
4. 皮肤创伤无瘢痕愈合机制研究;
5. 化妆品快速安全检测;
6. 生化分析及生物传感。
教学工作:
研究生:《实验数据处理及信息化技术》、《分子光谱分析》
本 科:《分析化学》、《大学化学》、《实验安全教育》
科研项目:
1. 主持国家自然科学基金青年项目,22004005,2021.01-2023.12;
2. 主持北京市教委一般项目,KM202110011011,2021.01-2023.12;
3. 主持男士微酸护肤科技研发项目,2025.12-2027.12
4. 主持新冠病毒检测项目,2022381,2022.10-2023.10;
5. 主持靶向制剂产业化合作项目,2024.06-2025.07;
6. 主持茉颜个性化服务化妆品项目,2024.05-2025.05;
学术兼职:
1. 北京理化分析测试技术学会核酸适配体交叉技术分会理事;
2. 中国老年学和老年医学学会抗衰老分会委员;
3. 北京神经内科学会基础与转化医学专业委员会委员;
4. 《Journal of Analysis and Testing》以及《香精香料化妆品》青年编委;
5. Analytical Chemistry、Biosensors and Bioelectronics等期刊审稿人。
科研成果:发表论文50余篇;申请专利20余项,参编专著1部,代表如下:
1. Liu, Y. X.; Hu, W. X.; Zhao, C. Y.; Zhao, C. K.; Liu, Y.; Pei, X*; Zhu, J.; Lyu, Y.; Qu, Z. H., pH-responsive nanocarrier: Chitosan- polydeoxyribonucleotide (PDRN) nanoparticles for transdermal nucleic acid therapy. Eur. Polym. J. 2026, 243, 114499.
2. He, H. F.; Zhao, C. K.; Li, J. Y.; Pei, X. *; Meng, H.; Zhang, Z., Hyaluronic acid-modified cationic nanoemulsion prepared by electrostatic self-assembly for improved specific targeting of keratinocytes and enhanced barrier repair efficacy. J. Drug Delivery Sci. Technol. 2026, 117, 108063.
3. Liu, Y. X.; Li, J. Y.; He, H. F.; Zhu, J.; Li, S. J.; He, Y. F.; Zhang, Z.; Pei, X.*, Hyaluronic Acid-Modified Nanoemulsions Enable Targeted Transdermal Delivery of Hydroxypinacolone Retinoate. Acs Applied Bio Materials 2026, 9, 380-389.
4. Liu, Y. X.; Zhan, X.; Zhu, J.; Pei, X.*, Preparation and Efficacy Validation of Dihydromyricetin Nanoliposomes. Current Pharmaceutical Biotechnology 2026. DOI 10.2174/0113892010422759251118151659.
5. Zhao, C.; Zhao, C.; Liu, Y.; Pei, X. *; Li, S.; Meng, H.; He, Y., Mechanism and Applications of Raman Spectroscopy in Cosmetics. Journal of Raman Spectroscopy, 2026; 0:1–20.
6. Liu, Y.; Hu, W.; Pei, X.*; Zhu, J.; Meng, H.; Lyu, Y.; Qu, Z., Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy. International Journal of Biological Macromolecules 2025, 322, 146984.
7. Xu, L., Liu, S., Huang, Z.,Pei, X.*. CRISPR-Cas12a Coupled with Universal Dual-mode Fluorescent Nanoparticles Platform for HPV Nucleic Acid Detection. J. Anal. Test. 2025,9, 153–159.
8. Xu, L.; Shang, Z.; Liu, D.; Zhao, C.; Zhao, C.; Pei, X.*; Zhang, Z., Preparation, characterization and efficacy of hyaluronic acid-modified two targeted liposomes for ectoin delivery to the skin. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2025, 719, 137013.
9. He, Y.; Shang, Z.; Pei, X.*; Yang, X., Capture-SELEX screening for a new nanomolar affinity aptamer for label-free detection of human MC1-R and applications potential in cosmetics. Microchemical Journal 2025, 219, 115931.
10. Li, J.; He, H.; Zhu, J.; Li, S.; He, Y.; Zhang, Z.; Pei, X.*, Preparation of hydroxypinacolone retinoate nanoemulsion with high stability, low irritation and high permeability. Journal of Drug Delivery Science and Technology 2025, 107, 106822.
11. Meng, H.; Hu, W. X.; Liu, D. X.; Zhang, Z.; He, Y. F.; Li, S. J.; Lyu, Y. B.; Sun, J. L.; Zhou, L.; Pei, X.*, Evaluation of the Application of Novel Smart Release Cooling Agent in Neurocosmetic Products. J. Sens. Stud. 2025, 40 (6), e70086.
12. Shang, ZL; Liu, ST; Liu, DX; Wang, Y; Pei, X*; Li, SJ; He, YF; Tong, YG; Systematically Investigating CRISPR/Cas12a Fluorescent Biosensor for Sensitive and Specific Single Nucleotide Variants Detection. Journal of Fluorescence. 2025, 35,11081-11089.
13. Liu, D.; Hu, W.; Shang, Z.; Pei, X.*; Sun, J.; Zhou, L.; He, Y.; Li, S.; Qu, Z.; Zhang, Z., Preparation and Characterization of a Novel Cooling Agent with Intelligent Response Long-Term Release Effect. Journal of Applied Polymer Science 2025, 142 (16).
14. Meng H., Xiong J., Hu W., Huang Z., Pei, X.* Flexible Nanoliposomes of Pterostilbene for Local Delivery: Potential for Increasing Skin Elasticity and Brightening Skin Effects. Current Pharmaceutical Biotechnology 2025.
15. He. Y.; Huang Z.; Yang X.; Dong Y; Pei X.*Advances on the mechanism and applications of stimulus-responsive DNA hydrogels Current Pharmaceutical Biotechnology 2025.
16. He H.; Pei X*; Zhang Z. Li S.;He Y.; Meng H. *, Yinmao Dong Preparation and Characterization of PDRN-Modified Ceramide Cationic Nanoemulsion (PDRN-CER-CNE) for Anti-Photoaging Cosmetics poster at the 35th IFSCC Congress 2025.
17. Wang Y., Peng Y., Liu S., Li M., Pei X* CRISPR/Cas12a coupled with loop-mediated isothermal amplification and lateral flow assay for SARS-CoV-2 detection Anal. Methods, 2024, 16, 5971.
18. Li, S.; Shi, W.; Wang, X.; Li, S.; Pei, X.*; He, Y., Electrospinning of gelatin nanofibers containing sesamol nanoparticles. Journal of the Textile Institute 2024, 115 (5), 844-852.
19. Xu, L.; Huang, Z.; Pei, X.*; Zhang, Z.; Li, S.; He, Y., Preparation and Characterization of Universal Liquid Proliposomes Encapsulating Water-soluble Efficacious Substances. Current Pharmaceutical Biotechnology 2024.
20. Shang, Z.; Liu, S.; Liu, D.; Pei, X.*; Li, S.; He, Y.; Tong, Y.; Liu, G., CRISPR/Cas12a with Universal crRNA for Indiscriminate Virus Detection. Molecules 2024, 29 (24).
21. Liu, S.; Huang, Z.; Luo, M.; Wang, Z.; Chen, H.; Zhang, Y.; Pei, X*, The Signal -Sensing Techniques and Recent Applications of CRISPR-Cas System. Spectroscopy and Spectral Analysis 2024, 44 (4), 918-924.
22. Liu, S.; Xu, L.; Huang, Z.; Zhang, Y.; Pei, X.*; Li, S.; He, Y., Recent advances of nanoparticles-assisted CRISPR/Cas biosensors. Microchemical Journal 2024, 199.
23. Huang, Z.; Meng, H.; Xu, L.; Pei, X.*; Xiong, J.; Wang, Y.; Zhan, X.; Li, S.; He, Y., Liposomes in the cosmetics: present and outlook. Journal of Liposome Research 2024, 34 (4), 715-727.
24. Deng, Y.; Zhang, Z.; Zhou, Y.; Pei, X.*; He, Y.; Wu, T., Introducing uracil-containing oligo to improve exponential amplification reaction performance in biosensor application. Microchemical Journal 2023, 191.
25. Liu, S.; Xie, T.; Pei, X.*; Li, S.; He, Y.; Tong, Y.; Liu, G. CRISPR-Cas12a coupled with universal gold nanoparticle strand-displacement probe for rapid and sensitive visual SARS-CoV-2 detection Sensors and Actuators B-Chemical 2023, 377, 133009.
26. Liu, S.; Xie, T.; Huang, Z.; Pei, X.*; Li, S.; He, Y.; Tong, Y.; Liu, G. Systematically investigating the fluorescent signal readout of CRISPR-Cas12a for highly sensitive SARS-CoV-2 detection. Sensors and Actuators B-Chemical 2022, 373, 132746.
27. Huang, Z.; Liu, S.; Pei, X.*; Li, S.; He, Y.; Tong, Y.; Liu, G. Fluorescence Signal-Readout of CRISPR/Cas Biosensors for Nucleic Acid Detection. Biosensors 2022, 12, 779.
28. Pei, X.; Hong H, Liu S. and Li N., Nucleic Acids Detection for Mycobacterium tuberculosis Based on Gold Nanoparticles Counting and Rolling-Circle Amplification Biosensors 2022, 12, 448.
29. Pei X.; Wu X.; Xiong J.; Wang G.; Tao G.; Ma Y.; Li N.; Competitive aptasensor for the ultrasensitive multiplexed detection of cancer biomarkers by fluorescent nanoparticle counting Analyst, 2020, 145, 3612−3619.
30. Pei X.; Tao G.; Wu X.; Ma Y.; Li. R; Li N.; Nanomaterial-based multiplex optical sensors Analyst, 2020, 145, 4111–4123.
31. Pei, X.; Lai, T.; Tao, G.; Hong, H.; Liu, F.; Li, N. Ultra-specific multiplexed detection of low-abundance single-nucleotide variants by combining masking tactic with fluorescent nanoparticle counting. Anal. Chem. 2018, 90, 4226−4233.
32. Pei, X.; Yin, H.; Lai, T.; Zhang, J.; Liu, F.; Xu, X.; Li, N. Multiplexed detection of attomoles of nucleic acids using fluorescent nanoparticle counting platform. Anal. Chem. 2018, 90, 1376−1383.
33. Pei, X.; Huang, H.; Chen Y; Li C.; Liu, F.; Li, N. Modulating fluorescence anisotropy of dye-labeled DNA without involving mass amplification. Talanta 2016, 154, 567−573.
34. 张钰婕,刘思彤,徐龙飞,裴晓静* 诗情“化”意——诗词中的化学;大学化学2023, 38, 1−5。
35. 詹鑫,刘宇欣,裴晓静*,祝钧,李姝静,何一凡,徐帆,李佳宇,复乳法制备二氢杨梅素脂质体。香料香精化妆品 接收。
36. 赵成可,刘东旭,赵彩云,尚振林,裴晓静*,李姝静,何一凡,大马哈鱼提取物化妆品应用分析综述。香料香精化妆品接收。
37. 张钰婕,于晨旭,张沛敏,裴晓静*等。虾青素脂质体的制备及其应用研究广东化工。2023,50(19):45-47.
38. 李思盈,吴韩,徐昌,裴晓静* 核酸及其衍生物在美丽健康领域的研究进展及应用 日用化学工业 接收。
39. 徐昌、李思盈、吴韩、裴晓静* 亚精胺生物活性以及化妆品应用进展香料香精化妆品 接收。
40. 吴韩、徐昌、李思盈、裴晓静* 透明质酸与多聚脱氧核糖核苷酸在皮肤修复中的协同机制与研究进展香料香精化妆品 接收。
41. 《CRISPR分子诊断技术原理及应用》人民卫生出版社2025(著作参编)
42. 基于CRISPR/Cas12a结合万能crRNA进行多种核酸检测的试剂盒 CN 119144704 B(专利 授权)
43. 一种核酸纳米微球及其制备方法和应用 CN120168501 B (专利 授权)
荣誉奖励:
1. 2024年 yl7703永利集团官网优秀班主任;
2. 2022年 yl7703永利集团官网优秀班主任;
3. 2020年 北京分析测试科技成果及青年人才成长评价优秀论文二等奖;
4. 2020年 主讲《分子光谱分析》获yl7703永利集团官网优秀课程思政建设课程;
5. 2020年 yl7703永利集团官网课程思政优秀教师三等奖;
6. 2018年 北京大学博士生国家奖学金;
7. 2018年 全国光谱大会青年论坛一等奖;
8. 2018年 获北京大学学术创新奖;
9. 2018年 获北京大学优秀科研奖;
10. 2016年 获北京大学化学与分子工程公司孙亦樑分析化学奖;
员工培养:
1. 2025年:研究生国家奖学金2人。
2. 2024年:研究生国家奖学金1人、本科生国家奖学金1人、北京市优秀毕业生1人;研究生学术之星1人。